Benefits of short-term dietary restriction in mammals

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A signature of renal stress resistance induced by short-term dietary restriction, fasting, and protein restriction

During kidney transplantation, ischemia-reperfusion injury (IRI) induces oxidative stress. Short-term preoperative 30% dietary restriction (DR) and 3-day fasting protect against renal IRI. We investigated the contribution of macronutrients to this protection on both phenotypical and transcriptional levels. Male C57BL/6 mice were fed control food ad libitum, underwent two weeks of 30%DR, 3-day f...

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Standardization of Short-term Benefits

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The functional costs and benefits of dietary restriction in Drosophila.

Dietary restriction (DR) extends lifespan in an impressively wide array of species spanning three eukaryotic kingdoms. In sharp contrast, relatively little is known about the effects of DR on functional senescence, with most of the work having been done on mice and rats. Here we used Drosophila melanogaster to test the assumption that lifespan extension through DR slows down age-related functio...

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ژورنال

عنوان ژورنال: Experimental Gerontology

سال: 2013

ISSN: 0531-5565

DOI: 10.1016/j.exger.2013.01.009